2022年疑似急性病毒性A型肝炎群聚事件：實驗室基因型分析

Laboratory Genotyping Analysis of Suspected Acute Hepatitis A Outbreaks, Taiwan, 2022

自2022年1月起，衛生福利部疾病管制署檢驗及疫苗研製中心分別接獲衛生福利部疾病管制署南區、中區及北區管制中心通報，進行疑似急性病毒性A型肝炎群聚事件分析。截至2022年7月底止，共計10起通報群聚事件，確定個案及其接觸者合計85例。其中26例為A型肝炎病毒核酸陽性，國籍皆為泰籍且基因型均為IA cluster 2，序列相似度為100%，確認為急性病毒性A型肝炎群聚事件。所有事件通報之泰籍移工，抵臺後並無再出境史，且陽性個案來臺工作時間已超過A型肝炎病毒之潛伏期。通報群聚事件分散於臺灣北、中、南各地，各地移工間並無彼此熟識之疫調關聯性，研判本次群聚事件應屬食因性感染急性病毒性A型肝炎病毒所致。

The Center for Diagnostics and Vaccine Development of Taiwan Centers for Disease Control was notified by the Southern, Central, and Northern Regional Centers of suspected acute hepatitis A outbreaks starting in January 2022. By the end of July 2022, 10 outbreaks were reported, involving 85 confirmed cases and contacts. Among the 26 cases that tested positive for hepatitis A virus using real-time PCR, all were Thai, and their genotypes were IA cluster 2. The sequence similarity was 100%, confirming an outbreak. No records of any of the Thai workers leaving Taiwan after their arrival were identified, and the positive cases had been working in Taiwan for longer than the incubation period of hepatitis A. The outbreak had cases scattered across northern, central, and southern Taiwan. Investigations found no apparent linkage among the cases, as they did not know each other. It was speculated that this year's outbreak was a foodborne infection of hepatitis A virus.