The new species Hoya lockii (Apocynaceae, Asclepiadoideae) was discovered in the Thua Thien-Hue Province of central Vietnam and is here described and illustrated. The morphological characters of H. lockii and its closely related species H. multiflora Blume are compared. Hoya lockii differs from H. multiflora in being pubescent in all parts of the plant except for the leaf blade and the corona, as well as in having white-opalescent corolla lobes and mucronate apex of corona lobes.