腦源性神經營養因子與阿茲海默氏症的關聯性

Correlation Between Brain-Derived Neurotrophic Factor and Alzheimer’s Disease

腦源性神經營養因子（Brain-Derived Neurotrophic Factor, BDNF）是大腦中豐富的多功能神經營養因子，BDNF對加強神經網絡非常重要，是中樞突觸功能的關鍵調節劑，當突觸功能產生障礙，即有可能產生如阿茲海默氏症（Alzheimer’s Disease, AD）的神經認知功能障礙疾病。本文於提升BDNF的方法層面，整理歸納BDNF和AD可能之關聯性的存在證據，此可分成直接（內源性）和間接（外源性）兩種路徑，目前的研究已證實，均衡營養素補給和規律運動是間接提升BDNF、改善認知功能的重要策略，而且兩者可相輔相成，期望這些資訊能在未來治療AD個案有所助益。

Brain-derived neurotrophic factor (BDNF) is amultifunctional neurotrophic factor that is abundant in the brain. It is especially important for strengthening neural networks and is akey regulator of central synaptic functioning. When synaptic functioning is disrupted, diseases of neurocognitive dysfunction, such as Alzheimer’s disease (AD), may ensue. The authors of this paper focused on methods to increase BDNF and compiled evidence of apossible link between BDNF and AD, which can be divided into two pathways: the direct (endogenous) and the indirect (exogenous). Existing studies have confirmed that abalanced nutrient supply and regular exercise are important strategies that indirectly increase BDNF and improve cognitive functioning, and that the two may complement each other. It is hoped that this information will be helpful in the future treatment of AD patients.