3D列印多孔性Ti6Al4V之真空鍍膜與生物相容性檢測

Three-Dimensional-Printed Porous Titanium Alloys for Vacuum Coating and Biocompatibility Testing

因Ti6Al4V材料的優異特性，是植入材微創手術中重要的材料之一，但Ti6Al4V植入材本身由於楊氏係數過高（高達100 GPa）和正常人骨（15~20 GPa）差異甚多，容易產生應力遮蔽效應，因此使用3D列印多孔性結構可降低植入材的楊氏係數，且已符合人骨的楊氏係數相似的優點。
本論文發展多孔性Ti6Al4V試片的真空鍍膜技術，研究主題為在3D列印多孔性Ti6Al4V試片表面鍍膜羥基磷灰石（Ca10(PO4)6(OH)2，簡稱HA）單層，再進行掃描式電子顯微鏡、附著力、抑菌及生物相容性等試驗，可以找出最佳鍍膜參數，並符合無細胞毒性要求。本論文中發現3D列印多孔性Ti6Al4V試片之羥基磷灰石以150 W鍍膜60 min的試片是無細胞毒性，其5天後細胞存活率為95.6%，而且抑菌效果最好，所以在150 W鍍膜60 min是最佳鍍膜參數。

Titanium alloy materials are ideal for use in implants; however, their high Young’s coefficient of up to 100 GPa makes them more vulnerable to the effects of stress shielding compared with normal human bone, which has a Young’s coefficient of 25–30 GPa. The Young’s coefficient of titanium alloy materials can be reduced using three-dimensional（3D）–printed porous structures.
In this study, 3D-printed porous titanium alloy specimens were vacuum coated with single-layer films of hydroxyapatite（Ca10(PO4)6(OH)2, HA）. To determine the optimal coating parameters and assess cytotoxicity, the specimens were subjected to structural equation modeling, adhesion, antibacterial, and biocompatibility tests. The specimens exhibited no cytotoxicity at a power output of 50 watts for 1 hour, a cell survival rate of 91.8% after 5 days, and the best antibacterial effect at a vacuum coating power of 150 watts for 1 hour.