維生素D與慢性鼻竇炎併鼻瘜肉的相關性

Relationship Between Vitamin D and Chronic Rhinosinusitis with Nasal Polyps

目的：本研究欲了解血清中維生素D濃度於鼻竇炎患者有無併發鼻瘜肉之相關性。方法：蒐集2017年6月至2018年6月接受手術治療的慢性鼻竇炎患者共41例，並按組織病理上有無合併鼻瘜肉分組。所有的病人均將門診檢查時所抽的血經離心後，約2毫升血清直接保存在4度C的冰箱中冷藏。以禮亞尚25-羥基總維生素D分析檢測試劑（LIAISON 25-OH-Vitamin D TOTAL Assay）來檢定。將測驗結果經統計分析比較其組間的差異。結果：41位接受慢性鼻竇炎手術之病人中，有26例因鼻竇炎併鼻瘜肉的病人作為研究組，平均年齡為48.8歲（男：女＝16：10）；有15例因鼻竇炎無合併鼻瘜肉病人作為對照組，平均年齡為44.48歲（男：女＝9：6）。經研究得出研究組病人血中25-羥基維生素D的濃度為20.48±5.88ng/mL，而對照組的濃度為21.09±5.61ng/mL。統計分析比較兩組之間血中的25-羥基維生素D濃度差異值為p=0.747，研究組的血清中25-羥基維生素D濃度比對照組低，但是統計結果上並無存在顯著差異，其中研究組有11人（11/26）缺乏維生素D（<20ng/ml），而對照組有7人（7/15）。結論：因統計分析比較兩組之間血中的25-羥基維生素D濃度其結果並無明顯差異，故本研究的結果不支持慢性鼻竇炎患者中25-羥基維生素D濃度的差異與併發鼻瘜肉之相關性。本研究總共41位病人血中的25-羥基維生素D濃度20.71±5.72（不足：20－40ng/mL）均為不足；是為慢性鼻竇炎患者的普遍現象。

Purposes: To determine the relationship between serum vitamin D concentration and the occurrence or non-occurrence of concomitant nasal polyps in patients with rhinosinusitis. Methods: A total of 41 patients who underwent surgical treatment for chronic rhinosinusitis between June 2017 and June 2018 were included in the study and divided into two groups based on the presence or absence of histopathologically confirmed concomitant nasal polyps. The blood sam-ples of all patients drawn during outpatient examination were centrifuged, after which 2ml of serum was obtained from each centrifuged sample and stored in a refrigerator at 4°C. Serum vitamin D concentration was measured using the LIAISON 25-OH Vitamin D TOTAL assay, and the resulting differences between the two groups were compared by statistical analysis. Results: Among the 41 patients who received surgery for chronic rhinosinusitis, 26 patients (male: female=16:10, mean age=48.8 years) were included in the nasal polyps (study) group, and 15 patients (male: female=9:6, mean age=44.48 years) were included in the non-nasal polyps (Control) group. The serum 25-OH vitamin D concentrations of the study and control groups were 20.48±5.88 ng/mL and 21.09±5.61 ng/mL, respectively. Statistical analysis revealed that the P value for the comparison of serum 25-OH vitamin D concentration between the two groups was 0.747. The serum 25-OH vitamin D concentration of the study group was lower than that of the control group; however, the difference was not statistically significant. Vitamin D deficiency (<20ng/ml) was found in 11 patients of the study group (11/26) and 7 patients of the control group (7/15).Conclusions: The statistically insignificant differences between the serum 25-OH vitamin D concentra-tions of the two groups indicate that the results of this study do not support the existence of a correlation between differences in 25-OH vitamin D concentration and concomitant nasal polyps. The average serum 25-OH vitamin D concentration of the 41 patients included in this study was 20.71±5.72ng/ml, which was considered to be deficient (deficiency: 20-40ng/mL); this is a common phenomenon among chronic rhinosinusitis patients.