中醫對於抗磷脂抗體引發反覆流產治療策略之文獻回顧

Literature review of traditional Chinese medicine on antiphospholipid antibodies induced recurrent pregnancy loss

反覆流產或稱復發性流產是生育期婦女的一個重要威脅。雖然其原因眾多，然而抗磷脂抗體造成反覆流產的重要性已日益受到重視，且在西方醫學體系也有了標準的防治策略，但中醫在此領域的研究仍屬有限。本文仿照系統性文獻分析，從三個資料庫搜尋了145篇文獻，進而予以評論並篩選，得到7篇可供參考的研究。進而探討各方各家不同的策略，包括：補腎活血清熱法、補腎化瘀安胎法、補腎健脾活血法以及日本中西併用法。而在單味藥分析，發現白朮、當歸、丹參、菟絲子、桑寄生、續斷、黨參分別為最常被使用。總結目前研究，中藥對抗磷脂抗體造成之反覆流產有其潛力，但有待大型嚴謹的隨機對照研究證實。

Recurrent pregnancy loss is a big threaten for child-bearing women. Through many causes were reported antiphospholipid antibodies have been recognized as an important causal factor. Moreover, the standard therapy has been developed in western medicine system. However, the investigation upon this field is still limited in TCM system. This review collected 145 articles from 3 databases and then assessed according to the principle of systematic review. Finally, only 7 oringinal articles were enrolled with relative accuracy.Furthermore, different therapeutic strategy from these experts were realized, which including invigoration kidney and promoting blood circulation and clearing heat, invigoration kidney and resolving macula for miscarriage prevention, invigoration kidney and strengthening spleen for promoting blood circulation and Dual therapy(Aspirin plus Kampo). Moreover, herbs used by different team were analyzed. Six kinds of herb (Baizhu, Danggui, Danshen, Tusizi, Xuduan and Dangshen)is most common prescribed. In brief, current TCM research upon antiphospholipid antibody related RPL seems to be potential, but needing a further randomized controlled study is mandatory.