肥胖對青黛油提取物軟膏治療乾癬的影響

The Influence of Obesity on Psoriasis Treatment with Indigo Naturalis Oil Extract Ointment

背景：研究證明乾癬嚴重度與肥胖之間的相關性，但在選擇乾癬的治療方法或評估治療結果時，醫師通常不考慮肥胖因素，本研究目的在探討肥胖對青黛提取物軟膏治療乾癬效果的影響。方法：我們從兩項臨床試驗中收集116例患者的數據，並根據體重指數（BMI）將患者分為三組：正常體重組（BMI＜25），超重組（25≤BMI＜30）和肥胖組（BMI≥30），我們比較各組間的治療反應結果，並分析相關代謝症候群的數據。結果：在治療反應方面，正常體重和肥胖組之間及超重和肥胖組之間的乾癬面積和嚴重度指數（PASI）％降低均有統計學差異（61.5％對26.8％，P=0.0093）（59.3％對26.8％，P=0.0207），但在正常體重和超重組間則沒差異。另外發現病人有高血壓和其他代謝紊亂疾病共病的治療反應比沒有共病者差。結論：乾癬治療應考慮肥胖和代謝合併症，肥胖患者使用青黛治療乾癬時，應處理其肥胖及代謝紊亂，以取得更好的治療反應，將來應進行更多的研究以基於患者的合併症，找出更有效的治療方法及藥物。

Background: The correlation between psoriasis severity and obesity has been verified; however, physicians generally do not consider obesity when they are selecting treatment methods for psoriasis or assessing treatment results. We evaluated the influence of obesity on psoriasis treatment involving indigo naturalis oil extract ointment. Methods: We collected the data of 116 patients from two clinical trials and divided these patients into three groups based on body mass index (BMI, kg/m^2), namely healthy weight (BMI ＜ 25), overweight (25 ≤ BMI ＜ 30), and obesity (BMI ≥ 30) groups. We compared their treatment response data (healthy weight versus overweight group, healthy weight versus obesity group, and overweight versus obesity group). Related metabolic data were also analyzed. Results: For treatment response, significant differences in Psoriasis Area and Severity Index reductions (%) were observed between the healthy weight and obesity groups (61.5% vs. 26.8%, P = 0.0093) and overweight and obesity groups (59.3% vs. 26.8%, P = 0.0207) but not between the healthy weight and overweight groups. Without obesity considered, patients with hypertension or other metabolic disorders (e.g., hyperlipidemia) that were verified by blood test data tended to exhibit slightly poorer treatment responses relative to patients without these conditions. Conclusions: Obesity and metabolic comorbidities should be considered by physicians in psoriasis treatment decisions; patients with obesity using indigo naturalis should be encouraged to manage their obesity to achieve better psoriasis treatment responses. Future studies should investigate whether patients' comorbidities influence the effectiveness of specific treatments.