Based on the social exchange theory, this study aimed to explore the relationships among human resource management practice, knowledge sharing, organizational innovation and perceived organizational support. Of the 800 questionnaires distributed to five-star hotel employees who have worked more than one year through the hotel managers who were willing to assist, 611 valid data were retrieved with a response rate of 76%. Research results indicated that (1) when hotel had better human resource management practice , employees were more likely to engage in knowledge sharing; (2) when hotel had better human resource management system, employees had more organizational innovation; (3) employees’ perception on organizational support had strengthen the relationship between human resource management practice and knowledge sharing. Research results can apply to strategic human resource management. Interactions and sharing among teams can produce knowledge as well as employees’ innovative behaviors. Furthermore, perceived organizational support can reinforce the relationship between human resource management practices, and employees’ knowledge sharing.