This article describes caring for a child with sepsis and acute kidney injury, who received continuous renal replacement therapy in the intensive care unit and her mother. The nursing period was from September 25 to October 6, 2017. The data were collected through direct care, physical assessment and family communication. The main nursing problems in this case study include: excessive body fluids related to acute kidney injury; risks of injury related to abnormal coagulation caused by sepsis; fear of hospitalization, separation from family, treatment; caregiver’s stress related to child’s illness, treatment, environment, and other caring issues. During the caring period, the nurse established a sense of trust with the patient and her family, provided individual care measures, improved her infection, breathing and oxygenation, monitored the hemodynamics, promoted the balance between body fluids and electrolytes, maintained his physical function, and met the needs of her body and mind, in addition to alleviating her family members’ anxiety by helping them understand of the patient’s condition and treatment.