Background: Chronic kidney disease is an important health issue in Taiwan. If the disease is not well-controlled, it will lead to dialysis treatment for patients with uremia. However, there is little discussion on the resilience and related factors of this ethnic group in Taiwan. Purpose: To explore the resilience and related factors among patients with pre-ESRD stage renal disease. Methods: This was a cross-sectional correlation study. Target patients were in the preESRD care program at a medical center in the Central District. The research tools consisted of demographic characteristics, Revised Ways of Coping checklist, chronic kidney disease self-efficacy instrument, and the Resilience scale. Result: A total of 201 patients who averaged 63.95 years of age and predominantly male were recruited. The result of the study showed that: (1) The overall patient had moderate resilience. (2) Monthly income status, kidney disease stage, problem-solving behaviors, and self-efficacy were predictive variables for resilience, and accounted for 58% of the total variation in resilience. Conclusion /Implications for Practice: Monthly income status, kidney disease stage, problem-solving behaviors, and self-efficacy were identified as the crucial predictive factors of resilience in pre-ESRD patients. CKD nursing staff should pay attention to the resilience and related factors of pre-ESRD patients. It is recommended that in-service education could incorporate resilience theory (such as resilience workshop) to provide nurses with communication skills in improving coping behaviors and self-efficacy among CKD patients, who then could effectively adapt positive strategies at home.