The aim of this study was to describe the effects of a music therapy program on the improvement of the self-esteem and stress relief in healthy older adults. A total of 12 female individuals and 2 caregivers voluntary enrolled in this study. The research was conducted primarily using the qualitative analysis that is accompanied by the quantitative method was applied to verify the quantitative data and the qualitative data mutually. The results of the study were derived from the semi-structured open questionnaire of qualitative research, and the Perceived Stress Scale (PSS) and Rosenberg Self-Esteem Scale (RSES) survey of quantitative research. The quantitative data analysis was used by Wilcoxon signed-rank test of nonparametric statistics. The 5 randomly selected interviewees included 4 older adults aged 65 years and above and 1 caregiver. After the sessions were completed, the results showed that that music therapy helped enhance self-esteem. No significant effects were found on stress reduction. All respondents explained that music, especially singing, plays an important role in stress reduction.