Iron-deficiency anemia is a common medical condition in everyday clinical practice. Oral or parenteral iron therapy is essential in treating patients with chronic iron-deficiency anemia. However, excess iron can be toxic and even fatal to human body. This article reports a case of iron intoxication presented with vomiting and hypotension due to wrong dosage of parenteral iron infusion with the purpose of reminding primary care physicians to understand the pathophysiology and clinical manifestations of iron intoxication so as to facilitate timely recognition, proper management, and necessary referral.