Purpose: The study aimed to identify the factors associated with Do-Not-Resuscitate consent among home care patients in a regional hospital. Methods: 454 patients receiving home medical care from the host regional hospital from 2016 to 2018 were recruited. Variables for analysis included demographic characteristics, palliativehospice care related non-cancer diseases, cancer history, activities of daily life, functional status, family support, and home medical care. Stepwise multivariable logistic regression was used to evaluate the factors associated with DNR consent. Results: As indicated by the results of stepwise multiple-logistic regression analysis, increase in the length of home medical care (OR 0.998, 95% CI 0.997-0.999) and no difficulty in verbal expression (OR 0.28, 95% CI 0.11-0.77) both decreased the chance of signing DNR consent. Other factors associated with DNR consent included family meeting (OR 29.78, 95% CI 15.60- 56.83), cancer history (OR 4.93, 95% CI 2.05-11.90), a hospice eligibility score of 4 points or higher (OR 2.64, 95% CI 1.45-4.79), and a doctor certified for palliative care (OR 2.63, 95% CI 1.01-6.84). Conclusion: The study revealed that cancer history, a doctor certified for palliative care, family meeting, and a hospice eligibility score of 4 points or higher tended to increase the chance of signing DNR consent, whereas increase in the length of home medical care and no difficulty in verbal expression were likely to reduce the chance. The findings suggest that medical home care team should provide its patients with DNR-related information as early as possible so as to facilitate a family meeting for increasing the chance of signing DNR consent.