ICU space design is related to the quality of medical care and the integration of multidisciplinary. However, the relative studies are insufficient and the design guidelines are deficient currently in Taiwan. This study use the Modified Delphi Method based on domestic and foreign literatures develops the questionnaire proposing 31 important score items and 14 selective items of planning and design elements for ICU. It selects 20 experts including hospital decision-makers, ICU attending physicians and their teams, and ICU ward nursing heads to participate in the Delphi research. Further, it uses statistic function to analysis whether the experts opinions converge. The results show that the overall consent convergence rate of experts was 95.56% and 43 iteams reach the agreement in three groups by the Kruskal-Wallis test. The consensus criteria are further defined by the definition of “high consensus” (Q.D.≦0.60) by Mead (1992), “very important” (Q1≧4, Q3=5) by Huang Youjie, Luo Shaolin (2001) , and the “consensus standard” view (P≧0.75) by Murry and Hommons (1995). This study summarizes the 25 key points as its design guidelines of ICU in Taiwan hospital. According to the three main axes, these 25 guidelines are divided to strengthening infection control, improving care efficiency and appropriate environmental design.