Occupational factors have been found to contribute to the development of cardiac and cerebrovascular diseases. Work stress, for example, may affect the nervous and endocrine systems, which in turn affects heart rate, blood pressure, metabolic factors, and endothelium. Previous studies have demonstrated that heavy workload might increase the risk of cardiac and cerebrovascular diseases, and the relative risk was around 1.1 to 1.4. According to studies from different countries, occupational factors contributed to 1% to 22 % of cardiovascular diseases. Several countries have listed cardiac and cerebrovascular diseases among compensable occupational diseases under certain specific conditions, and most cases in Taiwan are attributed to over-work. However, diagnosis of occupational cerebrovascular and heart diseases remains a challenging task. In practice, doctors should keep themselves updated with the latest revision of guidelines set forth by the government for identifying work-related cardiac and cerebrovascular diseases. More importantly, lifestyle modification and workload management should be implemented for disease prevention in high risk groups.