A 38-year-old male had suffered from left temporal area headache since ten years ago. The headache occurred about every two years and usually happened in May to July or when he was busy. Every time when the headache attacked him, it was located at left temporal area and was swollen pain in character. The frequency was once per day and the duration was one to two hours. It also happened at night that affected his sleep and day-time work. The headache was subsided with an analgesic but relapsed after the drug duration passing. The accompany symptoms were left eye pain, tearing, sneezing, and sometimes vomiting. There were no dizziness, vertigo, lighting, tinnitus or radiating pain. He had visited our Neurology out-patient department for headache in 2009 and was diagnosed as classical migraine difiately. The X-ray of cervical spine lateral view disclosed mild degeneration and the EEG showed normal data. This time, the left temporal headache relapsed on 10/22/2011. He then visited our Chinese Medicine department for the headache. Based on Chinese medical differential diagnosis, we prescribed Xiao-yao-san combined with Suan-pian-tang. The left temporal headache and associated symptoms improved after one week TCM treatment. During the third week of treatment, the headache was remissed. The TCM treatment persisted one month. After ten months, the headache did not relapse. In conclusion, Chinese medicine may be the complementary therapy of migraine and even can be the first choice of this intractable disease.