奈米技術應用於環境清潔消毒的效果

Evaluation of the antibacterial and antiepidemic of Bio-Kil nanotechnology at a medical center in central Taiwan

醫院發生醫療照護相關感染（healthcare-associated infections, HAIs）是國家醫療體系重大的經濟負擔。醫院的清潔度會影響到醫護人員與病人是否暴露在致病菌的危險環境之中。因此本研究與台灣中部某醫學中心合作，使用結合奈米微粒分子、四級銨（3-（trimethoxysilyl）-propyloctadecyldimethyl ammonium chloride）、與觸媒科技的物理防疫系統（Bio-Kil system），探討其在手術室的抑菌殺菌效果，以及對於院內空氣品質與水質的改善程度。經近一年的研究結果顯示：一、手術室30個取樣點，經由霧化處理後之平均總菌落數由49 CFU/cm2降為21.5 CFU/cm2，更甚於之前紫外燈殺菌的效果。二、呼吸照護中心的平均總菌數經自超過500 CFU/m3降至低於50 CFU/m3。三、八個加護中心暨病房共計44取樣點在介入放流後，水質不合格率幾乎都有顯著的降低改善，且其中28個出水口的退伍軍人菌數也不再不合格。四、於實驗室中證實，使用本奈米防疫系統霧化後，金黃色葡萄球菌與大腸桿菌都有顯著的抑制生長的能力。整體而言，使用本奈米防疫系統可使得空氣、水質及手術室的細菌獲得顯著的抑制，達到減少病原菌蔓延及HAI的機率，進而減輕醫療體系的負荷。（感控雜誌2020:30:153-166）

Healthcare-associated infections (HAIs) are a huge burden on individual hospitals and the healthcare system of a country. The cleanliness of the hospital environment determines healthcare professionals and patients' risk of exposure to microorganisms. The nano-epidemic prevention system (Bio-Kil) is an antimicrobial agent comprising inorganic metal components and organic quaternary ammonium compounds (QACs) that can effectively attract and kill pathogens. We cooperated with a medical center located in Central Taiwan for addressing and evaluating the application of the Bio-Kil system for the sterilization of an operating room and improvement in air and water quality. The number of bacteria significantly decreased from 49 CFU/cm2 to 21.5 CFU/cm2 in the operating room after atomized treatment, and this was better than the number resulting from UV light treatment. By constructing ceiling and floor-standing air purifiers in the respiratory care center, the number of bacteria in the air decreased from 500 CFU/m3 to 50 CFU/m3 . Both the rate of substandard samples and the number of Legionella species in water decreased. These results showed that the Bio-Kil system can effectively inhibit the growth of Staphylococcus aureus and Escherichia coli. In summary, setting up the Bio-Kil system in the hospital can help significantly reduce the number of bacteria in the air, water, and operating room. This can help protect medical professionals and prevent HAIs from exposure, decrease the generation of antimicrobial resistance, and, finally, significantly reduce the burden on the national healthcare system.