抗病毒免疫力相關基因IFIH1單核苷酸多型性rs1990760與狼瘡性腎炎的關係：橫斷面研究

Interferon Induced with Helicase C Domain 1 (IFIH1) Gene single nucleotide polymorphism rs1990760 and its correlation to lupus nephritis: a cross-sectional study

目的：探討IFIH1基因單核苷酸多型性rs1990760基因型與狼瘡性腎炎的關係。方法：蒐集於高雄長庚醫院確診紅斑性狼瘡並在風濕科追蹤六個月以上病人。臨床評估包含疾病活動度與實驗室數值，並檢驗IFIH1基因單核苷酸多型性rs1990760狀態。比較有無合併狼瘡性腎炎的兩組間，臨床資料與單核苷酸多態性rs1990760的相關性。結果：總計91位紅斑性狼瘡病患被收案，其中38人罹患狼瘡性腎炎。不論是否對年齡進行配對，具有TT合子的病患，與較低的狼瘡性腎炎盛行率相關。狼瘡性腎炎病患年紀較輕，疾病活動度較高，且血球之單核球比例較低。結論：本研究提供了IFIH1基因單核苷酸多型性rs1990760與狼瘡性腎炎盛行率關係的部份證據。

Objectives: The purpose of this study is to explore the relationship between Interferon Induced with Helicase C Domain 1 (IFIH1) gene single nucleotide polymorphism (SNP) rs1990760 and the clinical presentation of lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). Methods: This study included patients with a definitive diagnosis of SLE who were followed by the Rheumatology Department at Chang-Gung Memorial Hospital, Kaohsiung for at least 6 months. Clinical evaluations included disease activity measurements and clinical laboratory data. Comparisons of the rs1990760 SNP genotype between patients with and without nephritis were done in patients with SLE. Results: We enrolled a total of 91 patients with lupus in this study, 38 of whom were diagnosed with LN. Patients with TT homozygous allele were associated with a lower prevalence of lupus nephritis (p<0.05), both with and without age-matching. The patients with lupus nephritis were younger, experienced greater lupus disease activity, and had lower monocyte percentages. Conclusions: This study provides some evidence of a link between the IFIH1 SNP rs1990760 and the prevalence rate of clinical lupus nephritis.