| 英文摘要 |
Fast genetically-modified(GM) rodent production and shortened preclinical testing process are important for new drug development. Rats are the most commonly used animal in preclinical testing, but technical bottlenecks prevented the development of GM rats in the past, forcing researchers to conduct testing with GM mice. The National Laboratory Animal Center(NLAC) has successfully established a CRISPR/Cas(clustered regularly interspaced short palindromic repeats and CRISPR-associated nuclease system) technique that speeds up the genome editing process, and has also mastered technically-challenging 'rat pronuclear microinjection.' These methods not only accelerate the production of GM rats, but also greatly improve testing efficiency and precision. This breakthrough enhances the welfare of animals by reducing the number of animals required for a complete testing. |
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