Analysis and Confirmation of Synthetic Anorexics in Adulterated Traditional Chinese Medicines by high-performance Capillary Electrophoresis   全文下載

Analysis and Confirmation of Synthetic Anorexics in Adulterated Traditional Chinese Medicines by high-performance Capillary Electrophoresis

Six synthetic anorexics, clobenzorex, diethylpropion, fenfluramine, methamphetamine, phenylpropanolamine and phentermine, which can be found as adulterants in traditional Chinese medicines were assayed simultaneously by high-performance capillary electrophoresis. The electrolyte was a buffer solution containing 120mM phosphate buffer (NaH2PO4/H3PO4, pH 2.0) and 15% acetonitrile. Applied voltage was 16 kV and temperature was 30℃. Fluoren-2,7-diamnionium chloride was used as an internal standard and detector set at 200 nm. The recoveries of the synthetic anorexic adulterants in traditional Chinese medicinal formula using C8-SCX mixed solid-phase extraction were studied. Several traditional Chinese medicinal powders obtained from clinics were also studied by the above HPCE method and confirmed by GC-MS. Clobenzorex, diethylpropion and fenfluramine were found and determined in these samples. © 1999 Elsevier Science B.V. All rights reserved.