在反覆性經體外受精及胚胎植入後因著床缺陷而導致著床失敗之女性血清中Th17/Treg相關細胞激素比值較低

Decreased ratios of serum Th17/Treg related cytokines in women with a defect in implantation failures after in vitro fertilization

目的：比較反覆性經體外受精及胚胎植入後因為著床缺陷（人類絨毛膜性腺激素陰性）而導致著床失敗之女性及具有正常生育能力（對照組）之女性之間，血清中之第17型輔助T細胞／調節性T細胞相關之細胞激素比值是否有差異。方法：使用酵素免疫分析法來測量28位反覆著床失敗之女性及23位具有正常生育能力之女性血清中之介白質17，介白質23，介白質6，介白質10及移轉生長因子-β之濃度。結果：反覆著床失敗之女性之血清中第17型輔助T細胞相關之細胞激素／調節性T細胞相關之細胞激素之比值，包括介白質17／介白質10，介白質23/介白質10，介白質23/移轉生長因子-β，介白質6/介白質10，皆顯著地比正常對照組女性低。結論：血清中第17型輔助T細胞／調節性T細胞相關之細胞激素比值較低可能在著床缺陷之致病機轉上扮演一個角色。

Objective: To compare the ratios of serum T-helper type 17 (Th17) cell/regulatory T (Treg) cell related cytokines between non-pregnant women with repeated implantation failures (RIFs) after in vitro fertilization and embryo transfer (IVF-ET) cycles due to a defect in implantation and those with normal fertility (controls). Methods: Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentrations of IL-17, IL-6, IL-23, TGF-β and IL-10 in the serum of 28 women with RIF and 23 normal fertile women. Results: The ratios of Th17/Treg related cytokines, including the ratios of IL-17/IL-10, IL-23/IL-10, IL-23/TGF-β and IL-6/IL-10, were significantly lower in women with RIF due to a defect in implantation than those in controls. Conclusion: Decreased ratios of serum Th17/Treg related cytokines may play a role in the pathogenesis of a defect in implantation failure.