一位反覆性風濕症患者於罹患後天性A型血友病七年後發生紅斑性狼瘡：病例報告

Development of systemic lupus erythematosus seven years after presentation of acquired hemophilia A in a patient with palindromic rheumatism: a case report

後天性A型血友病是一種由於自發性製造對抗第八凝血因子之自體抗體而造成的罕見疾病。這種病患中大約半數是不明原因的，而大約百分之五和紅斑性狼瘡有關。就我們所知，在之前此類病患的個案報告中，所有的患者其後天性A型血友病皆是和紅斑性狼瘡同時發生，或是在診斷紅斑性狼瘡數年後才發生。在此我們報告第一例反覆性風濕症患者於罹患後天性A型血友病七年後才發生紅斑性狼瘡。

Acquired hemophilia A is a rare disease caused by the spontaneous development of autoantibodies against coagulation factor VIII. About half of these cases are idiopathic and 5% of them are associated with systemic lupus erythematosus (SLE). To our knowledge, in prior case reports of this cohort, acquired hemophilia A appeared concurrently with, or around 6 years after the development of SLE . Herein, we report the first case of a patient with palindromic rheumatism who developed SLE 7 years after acquisition of acquired hemophilia A.