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| 篇名 |
低劑量Azathioprine引起致命性全血球低下與先天性Thiopurine Methyltransferase缺乏：一病例報告及文獻回顧
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| 並列篇名 |
Life Threatening Pancytopenia with Azathioprine in a Systemic Lupus Erythematosus Patient |
| 作者 |
陳相成、張德明、郭三元、陳政宏、賴振宏 |
| 中文摘要 |
本篇報告描述一位三十八歲紅斑性狼瘡女性，因口服類固醇減量改為低劑量Azathioprine（0.75 mg/kg）於第五週產生嚴重骨髓抑制併全血球低下情形。經過停用Azathioprine一個月後，病患骨髓功能完全恢復。本為例乃文獻中第17例因服用低劑量Azathioprine（<3 mg/kg/day）於數週內產生極為嚴重的骨髓抑制，藉由此一病例及文獻回顧，此類病人有極大可能具有先天性Thioprine Methyltransferase缺乏，醫者應注意藥物引起極為嚴重的骨髓抑制，並於前三個月積極追蹤其血球變化。 |
| 英文摘要 |
Severe and rapidly evolving pancytopenia due to toxicity from low dosage ( < 3 mg/kg/day) azathioprine (AZA) in patients with autoimmune diseases is uncommon. We describe a 38-year-old woman with systemic lupus erythematosus (SLE) who developed pancytopenia 5 weeks after low-dose AZA (0.75 mg/kg/day) was started as a corticosteroid - sparing agent. After cessation of AZA, the clinical and hematologic abnormalities resolved. We report here a case of early and severe myelosuppression associated with AZA and review similar cases reported in the literature. |
| 起訖頁 |
23-31 |
| 關鍵詞 |
Azathioprine、Myelosuppression、Pancytopenia、Systemic lupus erythematosus、Thiopurine methyltransferase |
| 刊名 |
中華民國風濕病雜誌 |
| 期數 |
200312 (17:3、4期) |
| 出版單位 |
中華民國風濕病醫學會
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| 該期刊-上一篇 |
甲狀腺機能低下症酷似多發性肌炎一病例報告 |
| 該期刊-下一篇 |
類似全身性紅斑性狼瘡引起之腸道血管炎的單獨性腸道結核菌病症──病例報告 |
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