系統性紅斑狼瘡病人之抗Ro/ SSA和抗La/ SSB抗體

Anti- Ro/ SSA and Anti- La/ SSB Antibodies in Systemic Lupus Erythematosus

本研究對97位系統性紅斑狼瘡病人，檢查其血中之抗Ro/SSA和抗La/SSB抗體，其盛行率分別是40.2％和11.4％。比較此兩種抗體在臨床上的表現，帶有抗Ro抗體之病人較無此抗體的病人容易引起光敏感和免疫球蛋白增加。此兩種抗體和疾病的活動性並無關係，不會隨疾病的活動性改變而變動。抗ds DNA抗體之發生亦和此二種抗體無關。抗Ro和抗La抗體似乎傾向發生在發病年齡較大的病人。另更值得探討的是帶有抗La抗體的病人較少引起嚴重之腎臟病，此點似乎顯示該抗體可能是腎臟的保護因子。

Anti-Ro/ SSA and anti- La/ SSB antibodies were examined in 97 patients with systemic iupus erythematosus (SLE). The prevalence of anti- Ro/ SSA and anti-La/ SSB antibodies was 40.2% and 11.4%, respectively. There was an increased incidence of photosensitivity and hypergaitima- globulincmia in patients with anti-Ro/ SSA antibodies in comparison with those without. There was no significant correlation among anti-Ro/ SSA, anti- La/ SSB antibodies, and disease activity. These autoantibodies did not fluctuate with change of SLE activity. The incidence of anti-ds DNA antibodies did not correlate with these autoantibodies. There was a trend of increasing frequency of anti- Ro/ SSA and anti- La/ SSB antibodies in patients with older age of onset. Patients with anti-La/ SSB antibodies had a lower incidence of serious renal disease compared to those without these antibodies or those with anti- Ro/ SSA antibodies. This suggests that anti-La/ SSB antibody may be one of renal protective factors in SLE patients.