中國人系統紅斑狼瘡病人之補體四亞型分類

Complement C4 Allotyping in Patients with Systemic Lupus Erythematosus in Chinese

219位系統性紅斑狼瘡病人及231位正常對照組，曾進行補體C4A及C4B之分類。系統性紅斑狼瘡病人之C4BQ*0表現型頻率較正常人呈有意義之增加（相對危險度1.77, P = 0.0139），但C4AQ*0表現型之頻率，在系統性紅斑狼瘡病人卻未增加。系統性紅斑狼瘡病人之C4BQ*0表現型之頻率增加係因為繼發於和A33, B57, DR3等HLA抗原之不平衡連鎖遺傳。由本研究可得結論C4AQ*0或C4BQ*0並非造成國人系統紅斑狼瘡遺傳之主要因素，此點和西方人有所不同。

The complement components C4A, C4B were analyzed in 219 patients with systemic lupus erythematosus (SLE) and 231 control subjects. The C4B null allele phenotype frequency was significantly increased in SLE (p = 0.0139 with relative risk of 1.77), while C4A null allele was not increased in SLE. The increased frequency of C4B null allele was secondary to disequilibrium linkage with A33, B57 or DR3 in SLE. It's concluded that, unlike Caucasians, the C4A or C4B null allele is not an independent genetic factor for development of SLE in Chinese.