SLE患者的抗致癌性病毒抗體之研究

Prevalence of Anti- Oncogenic Virus Antibodies in SLE Patients

吾等曾將106例全身性紅斑性狼瘡(Systemic lupus erythematosus, SLE)患者及20名正常成人為對照組，詳查彼等對第一型人類T細胞白血病病毒(Human T-cell leukemia virus, typel HTLV-I)，B型肝炎病毒(Hepatits B virus)標誌，Epstein-Barr Virus 病毒(EBV)及Cytomegalovirus(CMV)四種致癌性病毒之抗體，與正常成人群比較。SLE患者群之抗HBV抗體及HBsAg之陽性率與正常群比較相差無幾，兩群之HBV感染雖常見，但HBsAg血症則少見。在SLE群之IgG及IgA之抗EBV之殼囊抗原(Virus capsid antigen, VCA)及抗早期抗原(Early antigen, EA)之抗體較對照組並無力價增高現象，但本研究發現SLE患者群之抗CMV抗體及抗HTLV-I抗體力價則遠較對照組為高。為何在SLE群僅有抗CMV與抗HTLV-I之昇高，而其他兩種病毒抗體則否？吾等曾列舉各種事實及參考文獻記載加以分析，結論認為CMV與HTLV-I之感染可能為SLE之併發現象，而無病因的重要性。

One hundred and six serum samples from patients with systemic lupus erythematosus (SLE) were studied for antibodies to oncogenic viruses: human T-cell leukemia virus, type I (HTLV- I), hepatitis B virus (HBV), Epstein- Barr virus (EBY) and cytomcgalovirus (CMV). HBV infection was common but HBs antigcnemia was not. IgG and IgA antibodies to both EBV capsid antigen (VCA) and early antigen (EA) were not significantly elevated. Strikingly high titers of anti-CMV were detected and five cases of positive anti-HTLV-I were encountered. These phenomena of common anti- HTLY-I and anti-CMV appear to be an effect rather than a cause of SLE.