| 英文摘要 |
Serum samples from 205 patients with rheumatic disorders were surveyed for anti- natural DNA (nDNA), anti- extractable nuclear antigen (ENA), anti- ribonucleoprotein (RNP), and anti- Smith (Sm) antigen by counter immunoelectrophoresis (CIE), and for fluorescent anti-nuclear antibody (FANA) by indirect immunofluorescent technique. Anti- nDNA was detected in 66.3% of patients with systemic lupus erythematosus (SLE) as well as other related diseases. Anti- ENA and anti-RNP were detected in SLE, rheumatoid arthritis (RA) and progressive systemic sclerosis (PSS). Anti- Sm was detected exclusively in SLE, 48.3% of the patients. FANA was positive in all 60 SLE patients and many of them showed speckled pattern in high titers. The sensitivities and specificities of the autoantibodies vary greatly and combined detections of anti- nDNA, anti-Sm and FANA can provide useful criteria for differential diagnosis among rheumatic disorders. However, no good correlation was made between these autoantibodies and the disease activity or major clinical manifestations. (J Rheumatol ROC 1984; 1:3-15). |
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