代謝症候群合併飲酒對肝臟酵素異常影響

Combined Effects of Metabolic Syndrome and Alcohol Drinking on Hepatic Enzyme Abnormality

目的：分析並探討代謝症候群合併飲酒對肝臟酵素異常之相關性及其影響因素。方法：採橫斷式研究設計，以「2005-2008台灣地區國民營養健康狀況變遷調查」資料庫中，19歲以上6,144位樣本為研究對象，扣除排除條件及遺漏值個案，共2,336位個案之代謝症候群指標、肝臟酵素及飲酒狀態資料進行分析。以多變項羅吉斯迴歸統計方法，校正其他變項之影響，分析影響代謝症候群和肝臟酵素異常之相關因子，及分析代謝症候群和飲酒狀態之交互作用對肝臟酵素異常之風險。結果：研究對象之代謝症候群盛行率為25.20％。在校正其他自變項後，年齡、教育程度、肝臟酵素、抽菸和嚼檳榔與代謝症候群呈顯著相關性。年齡、性別、腹部肥胖、高血壓、高三酸甘油脂、代謝症候群和飲酒與肝臟酵素異常呈顯著相關性。代謝症候群合併飲酒顯著提升肝臟酵素異常之風險。結論：代謝症候群透過飲酒行為會間接影響肝功能異常風險。因此，對有大量飲酒習慣者，亟需策劃健康生活型態，執行有效策略以降低代謝症候群及肝功能異常發生之風險。

Purposes: To analyze and discuss the correlation and influential factors of metabolic syndrome combined with alcohol drinking on hepatic enzyme abnormalities. Methods: This research is designed as a cross-sectional study. From the 2005-2008 Nutrition and Health Survey in Taiwan (NAHSIT) database, 6,144 samples aged 19 or above were selected as research subjects. After applying exclusion criteria and discarding samples with missing values, a total of 2,336 cases were selected and analyzed for their metabolic syndrome indicators, hepatic enzyme data, and alcohol drinking information. Multivariate logistic regression was applied to adjust for the effects of other variables, to analyze the correlation factors affecting metabolic syndrome and hepatic enzyme abnormalities, and to analyze the risk of interactions between metabolic syndrome and alcohol intake on hepatic enzyme abnormalities. Results: The metabolic syndrome prevalence rate of the research subjects was 25.20%. After adjusting for other independent variables, metabolic syndrome was significantly correlated with age, education, hepatic enzyme, smoking and chewing betel. Hepatic enzyme abnormalities were significantly correlated with age, gender, abdominal obesity, hypertension, hypertriglyceridemia, metabolic syndrome, and alcohol drinking. The combination of metabolic syndrome and alcohol drinking significantly increased the risk of hepatic enzyme abnormalities. Conclusions: Metabolic syndrome indirectly leads to abnormal hepatic functions through alcohol drinking. Therefore, it is necessary for heavy drinkers to live a healthy lifestyle and implement effective strategies in order to reduce the risk of metabolic syndrome and abnormal hepatic functions.