卵巢癌腦部轉移的檢視

Brain Metastases in Ovarian Cancer

卵巢癌轉移至腦部是少見的狀況，但隨著卵巢癌減積手術和化學治療的進步，這種狀況有逐漸增加的趨勢。不論原發性卵巢屬早期或晚期、分化是良好或很差、治療反應是有效或無效，在任何年齡和任何CA125值下，都無法預測誰會發生腦轉移。電腦斷層和磁振造影雖最能幫助診斷，但因不能常規應用，只有在患者出現腦部轉移症狀時才能使用。有腦轉移的病患均預後欠佳。在單一病灶、且身體沒有其他的轉移時，以積極合併手術、放射線、和化學藥物的治療，效果較單一療法為佳，但在多發性腦轉移者，祇有選擇放射線和化學治療。對某些特殊患者，經積極治療仍可能有不錯的效果。

Brain metastases in ovarian carcinoma are uncommon. However, an increased incidence of brain metastasis from ovarian carcinoma is probably associated with prolonged survival achieved by use of cytoreductive surgery and aggressive chemotherapy. In addition, detection of brain metastases is increasing due to improved methods of detection. It is difficult to find a correlation between the probability of development of brain metastasis and prognostic factors of ovarian carcinoma. Brain metastasis usually appears with a poor prognosis, however early diagnosis and aggressive multimodal treatment can improve the quality of life in patient. Current treatment for brain metastases include surgical resection, whole brain radiation therapy, stereotactic radiosurgery, chemotherapy, and various combinations of those therapies. Surgical resection remains the best therapeutic approach and should be considered in combination with chemotherapy and radiotherapy if the location and number of metastases allows it, in order to prolong survival.