中藥材中黃麴毒素污染之調查

Investigation on the Aflatoxin Contamination in Chinese Herbal Materials

為瞭解中藥材中黃麴毒素污染情形，本調查自96年至97年間在臺灣各地區中藥廠及中藥店，隨機價購女貞子(Ligustri Fructus)、神麴(Massa Medicata Fermentata)、小茴香(Foeniculi Fructus)、山楂(Crataegi Fructus)、延胡索(Corydalidis Rhizoma)、紅棗(Jujubae Fructus)、枸杞子(Lycii Fructus)、山茱萸(Corni Fructus)、蓮子(Nelumbinis Semen)、甘草(Glycyrrhizae Radix)、黃耆(Astragali Radix)、八角茴香(Anisi Stellati Fructus)、胡椒(PiperisFructus)、橘皮(Citri Reticulatae Pericarpium) 及大腹皮(Arecae Pericarpium)各20件，總計300件，採用食品中黃麴毒素檢驗法進行檢測，結果有287件符合規定，6件延胡索及7件蓮子發現含有超量之黃麴毒素，最高者（蓮子檢體）達429.5 ppb，是規定限量(15 ppb)之近29倍，而女貞子、小茴香、山楂、紅棗、枸杞子、山茱萸、甘草、黃耆、八角茴香及大腹皮則均未檢出。根據中藥廠及中藥房所提供之產地資料進行分析，發現12件不合格檢體之產地，均來自中國大陸。

This investigation was the first market survey conducted pursuant to DOH regulation of 11 October 2006 which imposed a rule for aflatoxin contamination limit of 15 ppb in a list of fifteen Chinese herbal materials.Total 300 samples, 20 each of the fifteen herbals, were collected in 2007 and 2008, mainly from local manufacturers who routinely process bulk materials from various supply sources. All samples were prepared and tested according to CNS standard 4090 N6097.Among the samples tested, 287 were found in compliance to the current rule. Among 13 samples failing the set limit, six were Corydalidis Rhizoma, and seven Nelumbinis Semen. Notably, an exceptional amount of 429.5 ppb was detected in one N. Semen sample. Tracing the source of the unlawful materials, 12 were documented as import from China and one remained unknown.