With improvements in medical techniques, the survival rates among patients undergoing dialysis are gradually increasing. Poor fluid control leads to overweight and related complications. It is therefore important that new strategies be developed to encourage and maintain fluid control in patients receiving hemodialysis treatment. Self-regulation theory is a model that could be used to develop new strategies. On the basis of this theory, this article aims to design an intervention protocol for fluid control in hemodialysis patients. Examples are provided to describe how such a protocol might be applied to improve the fluid control. It is hoped that through behavioral modification of fluid control, patients undergoing hemodialysis will maintain the interdialytic weight gain and that cases of cardiovascular disease resulting from fluid overload will be reduced.