比較傷寒論三個黃疸方劑治療奈異硫氰酸脂誘發大白鼠肝內膽汁滯流性黃疸的效果

COMPARATIVE EFFECTS OF THREE JAUNDICE DECOCTIONS FROM SHAN HAN LUN TREATED INTRAHEPATIC CHOLESTATIC JAUNDICE INDUCED BY ALPHANAPHTHYLISOTHIOCYANATEIN IN RATS

本研究目的在探討傷寒論三個黃疸方劑，治療奈異硫氰酸脂誘發大白鼠肝內膽汁滯流性黃 疸，比較其抗肝細胞損傷、膽道阻塞和膽汁鬱滯的效果。結果顯示：茵陳蒿湯對肝內膽汁滯流 性黃疸的療效最佳，梔子柏皮湯僅對膽道阻塞有顯著治療效果，麻黃連翹赤小豆湯僅對總膽紅 素有降低作用。此研究結果建議，凡由藥物、病毒等引起的急性肝內膽汁瘀滯及反復性肝內膽 汁瘀滯的病變，茵陳蒿湯可提供治療上的參考。 The purpose of study is to compare the effects of anti-liver cell injury, duct obstruction and cholestasis by three prescriptions including Yin chen hao Tan (YT), Zhi zi Bo pi Tan (ZBT) and Ma huang Lian qian Chi xiao dou Tan (MLCT) from Shan han Lun treated intrahepatic cholestatic jaundice induced by alpha-naphthylisothiocyanatein (ANIT) in rats. Results demonstrated that the effects of YT treated intrahepatic cholestatic jaundice included anti-liver cell injury, duct obstruction and cholestasis are significantly different from ZBT and MLCT. ZBT has a significant effect for duct obstruction. Ma huang Lian qian Chi xiao dou Tan (MLCT) has a significant decrease for total hyperbilirubinemia. The results suggest that the YT may offer a treatment reference for acute and recurrent intrahepatic cholestasis caused by drugs and viral infection.