葡萄柚汁與枳殼、化橘紅水煎劑中NARINGIN等雙氫黃酮類成分於人體內吸收之比較

Comparison of Flavanone Absorption of Grapefruit Juice with Herbal Decoctions of Zhigiao and Huajuhong in Healthy Chinese

Naringin為葡萄柚汁之主成分，被懷疑是與其他藥物發生交互作用的肇因成分之一。中藥枳殼及化橘紅之基原與葡萄柚皆為芸香科同屬植物之果實，其水煎劑中亦含豐富的naringin。本研究之目的為比較在健康中國人體內葡萄柚汁與這些中藥水煎劑中naringin等雙氫黃酮類成分之吸收情形。本研究以六名自願之健康男性分別服用1000ml機器現榨之葡萄柚汁，收集尿液36小時。尿液樣品經β-glucuronidase/sulfatase水解後，利用HPLC方法定量其中naringenin。葡萄柚汁中naringin等雙氫黃酮類成分之吸收情形，經與服用10g枳殼之水煎劑或10g化橘紅之水煎劑的結果進行比較，結果顯示中藥枳殼及化橘紅水煎劑中naringin等雙氫黃酮類之吸收速率快於葡萄柚汁，而且吸收總量與吸收百分率亦高於葡萄柚汁。若naringin或narirutin之代謝物確為葡萄柚汁發生藥物交互作用之原因，則枳殼及化橘紅水煎劑與其他藥物之併用不可不慎。

Naringin is the major constituent of grapefruit juice and it is suspected to be one of the causative agents for grapefruit juice-drug interaction. Decoctions of Citri Aurantii Fructus (zhiqiao) and Citri Grandis Pericarpium (huajuhong) whose origins are of the same genus as grapefruit are rich in naringin contents. The aim of this study was to compare the flavanone absorption of grapefruit juice with these two herbal decoctions in healthy Chinese. 　　Six healthy volunteers were given 1000 mL of grapefruit juice and urine was collected for 36 hr. After hydrolysis with β-glucuronidase/sulfatase, naringenin in urine was assayed by HPLC method. By comparing the flavanone absorption of grapefruit juice with those of herbal decoctions obtained in our previous studies, the results indicated that flavaone absorptions of these herbal decoctios are faster in rate, higher in extent and also higher in absorption percention percentage than that of grapefruit juice. 　　If the metabolite of naringin or narirutin is indeed the causative agent for drug interactions, then the coadministration of these herbal decoctions with other western western medicines should be with caution.