燙傷使用中藥外敷之研究

Research of the Chinese Herbs Applied on the Animal after Thermal Injury

本實驗以紫雲膏(Zi-Yun-Gao)為主的中藥來評估中藥對紐西蘭家兔(New Zealand Rabbit)深Ⅱ度燙傷的療效。結果顯示，中藥各組及西藥組比對照組的燙傷創面脫痂時間(fall-off time of scab)明顯縮短(p<0.05)，且從病理切片得知，紫雲膏及加味紫雲膏(Jia-Wei-Zi-Yun-Gao)更能提高巨噬細胞、淋巴球及纖維母細胞之數量，同時亦增加表皮和毛囊的再生能力。血清中CPK(creatine phosphokinase)值的變化方面，紫雲膏組的脫痂時間明顯短於西藥組及對照組(p<0.01)。且紫雲膏組血清中CPK於第二天即降至正常，此說明紫雲膏在燙傷初期抑制創面下組織損傷的能力較佳。

This experiment is to assess the effect of therapy with Zi-Yun-Gao of Chinese herbs on Ⅱ degree deep burn in New Zealand rabbits. The results show that the fall-off time of scab in the Chinese herbs and Western medicine groups are evidently shorter (p<0.05) than in the control groups. In addition, we learn from the pathologic biopsy that Zi-Yun-Gao and Jia-Wei-Zi-Yun-Gao can greatly increase the quantity of macrophages, lymphocytes and firbroblasts, and that they also increase the regeneration ability of the epithelium and hair follicles. As to the change of the value of CPK (creatine phosphokinase) in the serum, the fall-off time of scab in the Zi-Yun-Gao group was markedly longer than the Western medicine and the control (p<0.01) groups. Moreover, the CPK in the serum with Zi-Yun-Gao decreases to normal by the second day, which is to specify that in the initial stage of burn, Zi-Yun-Gao has greater ability to restrain the injury tissue under wound surface.