補陽還五湯降血脂作用

Antiatherogenic Effect of Pou Yan Fan Wu Tan in Hypercholesterolemic Rat

補陽還五湯搜載在清朝醫林改錯，主治中風後半身不遂，口眼歪斜，語言蹇澀，口角流涎，大便乾燥，小便頻數，遺尿不禁，其藥材為黃耆，桃仁，川芎，歸尾，赤芍，地龍干，藏紅花，本方用的方劑組成為黃耆 150g，桃仁 7.5 g，川芎 5.6 g，歸尾 7.5 g，赤芍 7.5 g，地龍干 7.5g，藏紅花 1.775g，加水於 100 ℃下煮沸一小時，過濾並收集濾液，藥渣再依同法處理共二次，合併二次濾液，經減壓濃縮後得粗抽取液，進行藥理實驗，所得結果如下：（一）補陽還五湯對正常的大白鼠的總膽固醇及三酸甘油脂的作用。每天早晚二次口服補陽還五湯粗提取液5 gm/kg 一星期後對正常的大白鼠的總膽固醇及三酸甘油脂有意義的減少。（二）誘導高血脂的大白鼠。1. 誘導一星期，三星期，四星期高血脂的大白鼠，其總膽固醇及三酸甘油脂皆比正常值有意義增高。2. 誘導一星期，三星期，四星期高血脂的大白鼠，再每天早晚二次口服補陽還五湯 5 gm/kg 一星期後，分別測得總膽固醇及三酸甘油脂皆有意義的減少。3. 誘導一星期，三星期，四星期高血脂的大白鼠，再每天早晚二次口服補陽還五湯 5 gm/kg 一星期後，高密度脂蛋白含量沒有影響。由以上實驗結果得知，本方補陽還五湯對正常的大白鼠及誘導高血脂的大白鼠皆能有意義的降低其中總膽固醇及三酸甘油脂的含量而高密度脂蛋白含量則沒受到影響。

Pou Yan Fan Wu Tan was originally reported in the book Yi Lin Gay Chou in Chin Dynasty. Its principle indications are mainly for stroke-induced paraplegia, twisted eyes and mouth, inability to speak, involuntary salivation, dry feces, polyuria, and dripping urea. All the components including 150 gm of Hwang-Chi, 7.5 gm of Tau-Jen, 5.6 gm of Chwang-Chone, 7.5 gm of Guai-Wei, 7.5 gm of Chi-Shou, 7.5 gm of Di-Long-Gan and 1.775 gm of Cang-Hon-Hwa are extracted via distillation and concen-trated to obtain crude extracts for subsequent pharmacological experiments. The results are as described:A. Administration of 5 gm/kg Pou Yan Fan Wu Tan twice perday can significantly reduce total cholesterol and triglycerideslevels without changing HDL levels in normal rats. B. Induction of hyperlipidemia in rats. 1. Rats with one, three or four weeks of hyperlipidemia induction showed a significant increase in total cholesterol and triglycerides levels as compared to normal rats. 2. Rats with one, three or four weeks of hyperlipidemia induction with subsequent administration of 5 gm/kg Pou Yan Fan Wu Tantwice perday for one week showed a significant decrease in total cholesterol and triglycerides levels as compared to controls. 3. Rats with one, three or four weeks of hyperlipidemia induction with subsequent administration of 5gm/kg Pou Yan Fan Wu Tan twice perday for one week showed no change in HDL level as compared to controls. In summary, our results showed that Pou Yan Fan Wu Tan with our special prescription can effectively reduce total cholesterol and triglycerides levels without altering HDL level in either hyperlipidemia or normal rats.