眼科民間藥用植物－－皺葉萵苣之成分研究

Study on the Constituents of the Ophthalmic Folk Medicines - Lactuca sativa L. var. crispa L.

台灣產皺葉萵苣Lactuca sativa L. var. crispa L.為民間廣為食用之治療眼疾及眼睛保健蔬菜。其根部和葉部的甲醇萃取物，藉由多次管柱層析分離及純化，並用EI－MS，FAB－MS，IR。1H－NMR，13C－NMR等光譜分析技術鑑定成分的化學結構。結果分離到三個triterpenoid（taraxerol，taraxerone，β－amyrin），兩個methylbenzoate還有uracil及三個essential amino acid。其中化合物β－amyrin，據文獻報導，它能促進網膜色素上皮（RPE）細胞吞噬作用。

Three known triterpenoid (taraxerol, taraxerone. β-amyrin), two methylbenzoate, uracil mid three essential amino acid were isolated from Lactuca sativa L. var. crispa L. of the Ophthalmic Folk Medicines in Taiwan. Among these compounds, β-amyrin, according to literature, can enhance Retinal Pigment Epithelial (RPE) cell phagocytosis. Structure determination was carried out by spectral techniques such as, EI-MS, FAB-MS, IR, 1H-NMR arid 13C-NMR.