英文摘要 |
The aim of this study was to investigate the effect of almond on the pathogenesis of dextran sulfate sodium (DSS)-induced colitis in rats. 7-wks-old male Wistar rats were assigned to 2 groups (n=8), control group (C) and 5% almond water-fed group (A). After 5-wks feeding, rats were induced colitis by receiving 2% DSS (w/v) in their drinking water for 5 days. During the acute colitis, clinical manifestations and disease activity index (DAI) were recorded everyday. All rats were killed at day 8, blood and colon were collected for further analysis. Our results showed that rats treated with almond caused a decrease in DAI at day 2, this ameliorative effect mainly was attributed to the reduction of gross bleeding. There were no differences in body weight gain, serum GOT and GPT activities between the two groups. The length of colon, TBARS, GSH content and superoxide dismutase (SOD) activity in colon didn't differ between the two groups. Therefore, we suggested that almond water could ameliorate the progression of DSS-induced acute colitis in rats, but the protective mechanisms of almond need to further explore. |