中草藥乙醇萃取物之抗發炎功效比較

Anti-inflammatory Activities of Ethanol Extracts of Chinese Herbal Medicines

中國草藥經典中，詳載多種具有清熱解毒功效的中草藥，本實驗擬就其中七種，包括：白花益母草（Leonurus sibiricus）、使君子（Quisqualis indica）、蒼耳子（Xanthium strumarium）、化石草（Orthosiphon aristatus）、雞屎藤（Paederia scandens）、鳳尾草（Pteris multifida）及白花蛇舌草（Hedyotis diffusa），以對抗脂多醣（LPS）誘導之小鼠巨噬細胞RAW264.7的一氧化氮（NO）生合成，比較其抗發炎功效。結果顯示，蒼耳子及鳳尾草之乙醇萃取物，可以明顯的抑制由LPS誘發細胞生成的一氧化氮，且無明顯的細胞毒性產生，因此具進一步深入研究或開發成保健食品之潛力。

The aim of this research is to compare the anti-inflammatory activities of seven ethanol extracts of Chinese herbal medicines, Leonurus sibiricus, Quisqualis indica, Xanthium strumarium, Orthosiphon anistatus, Paederia scandens, Pteris multifida and Hedyotis diffusa. Our results showed that the ethanol extracts of X. strumarium and P. multifid were potent in inhibiting nitric oxide production in LPS-stimulated RAW264.7 macrophages without causing adverse cytotoxicity in the test range. Therefore, these two Chinese herbs may present potential targets for health food development.