Background and purpose: The effect of philosophy courses on medical college stu-dents in a worthy issue, the pilot study explored the effect of “philosophy of life” courses on the spiritual well-being of occupational therapy students. Methods: The participants were 34 occupational therapy students from a university in New Taipei City, the participants completed three times “Shalom scale” in the third week of the first semester, sixteenth week of the first semester, and the sixteenth week of the second semester. The differences in “Shalom scale” results were calculated by SPSS 20.0. Results: The average scores of the students in the “Shalom Scale” showed successive increases, but it did not reach a statistically significant value. Conclusion: The average scores of occupational therapy students’ sense of spiritual well-being increased after taking the philosophy of life course. In the future, larger sample sizes and more research equipments can be used to explore the benefit of philosophy of life courses to medical education.