Background and Purpose: The purpose of this report is to discuss the challenges and procedures for the safety management and vaccination protocol for nurses in rela-tion to COVID-19. The lack of which dictates that nurses must possess advanced nursing skills, especially in the field of vaccination protocol. Methods: Six professional registered nurses (RN) and two leader nurses in the community health center were engaged in individual interviews regarding the Covid-19 vaccine distribution, and the related safety practice issues between July 2021 to December 2021. Results: A crucial factor between a client and a nurse’s interaction and communication is related to the lucid understanding of vaccine determinants in the distribution of the vaccine using a proper framework. Nurses also require updated information for their duties in these truly unpredictable times. Conclusion: Precautional safety taken within the allocation and control of vaccines for public use will give credence to correct vaccine management procedures that can augment a more effective relationship and better communication between nurses and the public.