Background and purpose: Schizophrenia is a serious contemporary mental illness, and many previous investigations have demonstrated that singing is beneficial to people’s mental health, including religion songs. However, few investigations have utilized therapeutic factors to study the benefits of group religion song singing to pa-tients with chronic schizophrenia. The purpose of this investigation is to compare the therapeutic factors between Christian song singing group and free-style singing group of patients with schizophrenia. Methods: This investigation gathered 38 patients with chronic schizophrenia, living at two residential institutions for psychiatric rehabilita-tion, as research subjects. They participated in two singing groups: Christian song singing group, and a general singing group. The differences in therapeutic factors be-tween the two singing groups were analyzed using a therapeutic-factors assessment tool after eight weeks of study. Results: Analytical results show that patients felt more favorably about group religion song singing than about general free-style singing ac-tivity for all 12 therapeutic factors. Additionally, female patients tend to experience “catharsis” more than their male counterparts in therapeutic singing groups. Education level has no influence on therapeutic factors, and age is negatively correlated to three therapeutic factors, namely developing socializing techniques, instillation of hope and existential factor. Conclusion: This study concludes that group religion song singing offers more therapeutic benefits than general free-style group singing for schizophre-nia patients. The latter group therefore is worthy of further promotion.