Objectives: Work–life balance is associated with productivity and work performance, and among health care workers, poor work performance can be detrimental to patient safety.
Methods: This study used the new version of the Safety Attitudes Questionnaire (NEW-SAQ) developed by Joint Commission of Taiwan. Hierarchical regression was used to verify the research hypothesis.
Results: The interaction between patient safety culture and resilience had no significant effect on work–life balance, whereas resilience had a significant positive effect on work–life balance.
Conclusion: The average scores of patient safety culture and resilience did not affect each other but had significant effects on work–life balance. In particular, resilience had a highly significant positive effect. Hospitals should encourage health care workers to improve their resilience, problem-solving skills, stress management skills, and mindfulness, because doing so improves work–life balance and thus patient safety.