Objective: To evaluate on the factors related to the willingness of nurses to take care of emerging infectious diseases in designated emergency hospitals in Taipei. Methods: Designed for a cross-sectional study, a structured questionnaire survey was conducted on a total of 255 clinical nursing staffs who had been practicing for three months in a designated (regional) hospital in Taipei from July to August 2021, in-cluding demographic attributes and nursing staff The professional commitment scale, self-efficacy scale, care attitude scale, and willingness to care were analyzed by single factor variance analysis, correlation coefficient and regression. Results: The average score of nursing staff’s willingness to care for emerging infectious diseases was 6.7 (standard deviation 2.55), which was statistically significantly different from their work units and whether they had participated in practical training courses; while nurses’ professional commitment and willingness to care (r = 0.26,p<.01), self-efficacy and willingness to care (r = 0.20, p<.01), behavioral beliefs and will-ingness to care (r =0.30, p<.01) in care attitudes, results in care attitude Both evalua-tion and willingness to care (r =0 .27, p<.01) showed a low degree of positive corre-lation. Based on the analysis results, the behavioral belief dimensions of work unit, professional commitment, and care attitude after controlling for the demographic changes can explain 34.2% of the total variation of the study subjects’ willingness and all reach statistically significant differences. Conclusion: More than 60% of nursing staff have the willingness to take care, but the study found that their professional commitment scale average is low as 3.34 (by Liker’s method). Nowadays, the medical and nursing environment is changing rapidly. The hospital is facing the problem of health insurance payment and nursing staff turnover or not wanting to engage in nursing work after graduation. The study found that job satisfaction and professional commitment are positively correlated, and the scores of job satisfaction and profes-sional commitment also imply the predictability of nursing staff to leave the organiza-tion or professional workplace. In view of the current generation’s emphasis on be-longing and the desire to be valued, nursing staff are actively provided with space and opportunities for growth and are given appropriate motivation and support environ-ment to enhance their loyalty and stability in line with their performance, which will encourage nursing staff to continue to work hard for the nursing profession.