2019至2023年間台灣族群HLA抗體的盛行率

The prevalence of anti-HLA antibodies in Taiwanese populations from 2019 to 2023

本研究旨在評估台灣族群中HLA抗體的盛行率與分布，回溯分析2019年至2023年間於國立台灣大學醫院檢測的600個樣本，使用Luminex平台的Single Antigen Bead （SAB）技術進行HLA抗體的檢測，以平均螢光強度（MFI）≧1000作為陽性判定標準。研究結果顯示，HLA class I與class II抗體的陽性率分別為59 %與51 %。透過熱圖分析HLA抗體的整體分布，class I抗體主要集中於HLA-A與HLA-B基因座，而class II抗體則集中於HLA-DR與HLA-DQ基因座，且抗體的基因座分布與MFI強度具明顯差異。本研究結果提供重要參考依據，有助於未來提升移植前免疫學評估與術後監測的精準性。

This study aimed to evaluate the prevalence and distribution of HLA antibodies in the Taiwanese population. We retrospectively analyzed 600 samples tested at National Taiwan University Hospital between 2019 and 2023 using the Luminex Single Antigen Bead (SAB) assay to detect HLA antibodies, considering a mean fluorescence intensity (MFI)≧1000 as positive. Results showed positivity rates of 59% for HLA class I and 51% for HLA class II antibodies. Heatmap analysis revealed distinct antibody distribution patterns, with class I antibodies primarily targeting HLA-A and HLA-B loci, whereas class II antibodies predominantly targeted HLA-DR and HLA-DQ loci. Additionally, there were significant differences in antibody distribution across loci and in MFI intensities. This study provides critical data for enhancing the precision of immunological assessment prior to transplantation and subsequent post-transplant monitoring.