磁振導引高能聚焦超音波在原發性震顫中的應用

磁振導引高能聚焦超音波(MRgFUS)為非侵入性技術，透過磁振造影(MRI)即時引導高強度聚焦超音波進行精準治療。在腦部的應用中，MRgFUS被用於巴金森氏病引起的顫抖、原發性震顫的緩解及多項神經系統相關疾病之治療。此技術可藉由熱消融(thermal ablation)消除異常神經核團，或透過開啟血腦屏障，促進藥物送達腦內等，以進行多項治療。研究證明，MRgFUS相較於傳統手術，具備無創、恢復期短及低併發症風險等優勢。然而，腦部病灶位置的選擇與治療過程中的溫度控制，仍是技術發展的挑戰。總體而言，MRgFUS在神經系統疾病的非侵入性治療上展現了極大潛力，未來更多臨床試驗和技術改良，將進一步擴大其應用範圍。

Magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive technology that uses highintensity focused ultrasound precisely guided by magnetic resonance imaging (MRI) for treatment. In neurological applications, MRgFUS is employed for alleviating Parkinson's disease-related tremors, essential tremor, and various other neurological disorders. This technology achieves therapeutic effects through thermal ablation, which eliminates abnormal neural nuclei, or by temporarily opening the blood-brain barrier to enhance drug delivery to the brain. Research have demonstrated that MRgFUS offers advantages over traditional surgery, including noninvasiveness, shorter recovery times, and lower complication risks. Overall, MRgFUS shows significant potential as a non-invasive treatment for neurological diseases, and future clinical trials and technological advancements are expected to further expand its range of applications.