磁振導引高能聚焦超音波燒灼術用於治療巴金森氏病與深腦刺激術療效之比較

磁振導引高能聚焦超音波燒灼術，是治療巴金森氏病的一個新技術。過去針對巴金森氏病的功能性神經外科手術，主要是需要開顱進行的病灶切除術或是深腦刺激術，而這些治療所針對的標靶神經區域，也成為目前磁振導引高能聚焦超音波燒灼術的標的，用以緩解動作障礙。磁振導引高能聚焦超音波燒灼術的最大優點，在於不需要開顱手術以及沒有麻醉風險，不過也是有一些執行上的限制，以及已經可能存在的不良反應。筆者透過文獻回顧的方式，整理近年磁振導引高能聚焦超音波燒灼術的成效和不良反應報導，並且與使用深腦刺激術治療巴金森氏病的療效加以比較，旨在提供臨床醫師更多的參考資料，藉以了解如何選擇每位巴金森氏病人最適合的治療方式。

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging technique for the treatment of Parkinson’s disease (PD). Historically, functional neurosurgery for PD have primarily involved lesioning procedures or deep brain stimulation (DBS), both of which target specific neural regions to alleviate motor dysfunction. These same target areas have become the focus of MRgFUS, which offers the advantage of being a non-invasive procedure without the risks associated with craniotomy or anesthesia. However, there are certain limitations in its implementation, as well as potential adverse effects. Through a comprehensive literature review, this study examines the recent outcomes and reported side effects of MRgFUS, comparing its efficacy with that of DBS in the treatment of PD. The goal is to provide clinicians with additional reference material to better understand how to select the most appropriate treatment for the purpose of individualized PD treatment.