以金屬咪唑材料ZIF-8開發傳統木建築生物防治長效釋放用藥之合成與測試

Synthesis and Performance of Hybrid Zeolitic Imidazolate Frameworks-8 for Long-Term Biological Control of Traditional Timber Buildings

近年來，文化資產保存技術朝向更加環保與永續發展的方向發展，而古蹟常見以木材為主要建材，現行之木材生物防治方法仍存有污染環境與有害人體的疑慮，因此現行技術明顯已不符合未來對於環境永續與安全無害的發展趨勢，而近年研究發展趨勢即是使用綠色製程以及以奈米技術達到文化資產保護的目標。有鑑於此，本研究開發符合綠色化學要求之室溫水合成法，合成奈米級有機金屬骨架材料：沸石咪唑酯骨架材料（Zeolitic imidazolate framework, ZIF-8），並結合生物費洛蒙：丁酸丁酯，以達到具針對性防治之目的。有機金屬骨架材料種類繁多，ZIF-8具有較佳的抗候性與熱穩定性，因此較適合作為古蹟防護之用。ZIF-8與費洛蒙藥物載入製程均為本研究自主開發合成，產物透過X光繞射、動態光散射、掃描式電子顯微鏡、熱重分析等多項技術分析確認可成功合成奈米級之ZIF-8，其粒徑尺寸僅約134 nm，且丁酸丁酯能順利載入ZIF-8之中且能穩定長效釋放。

Recently, the cultural heritage preservation technology has focused on enabling environmentally-friendly preservation and sustainable development. Among various historical monuments, timber is considered as one of the materials in the typically built. Accordingly, the development of novel materials for the biological control is essential. However, there have been limited applications from such class of biological control methods mainly due to them pollute the environment and often harmful to humans. New perspectives have been opened by the application of materials science and nanotechnology to biological control methods, generating a breakthrough in the development of innovative tools for the conservation and preservation of typically built.
In this context, a series of nano-scale zeolitic imidazolate framework (ZIF-8) with different particle sizes, morphology, stability, and reagent release behavior was explored through green chemistry method of room-temperature hydrothermal synthesis and joint experimental−computational exploration. The nano-scale ZIF-8 not only showed good chemical resistance and thermal stability against various harsh circumstances but also displayed the delivery properties for protecting historical monuments. In this work, a nano-scale ZIF-8 with butyl butyrate (B) as biological pheromone was characterized by powder X-ray diffraction (P-XRD), dynamic light scattering (DLS), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The resulting nano-scale ZIF-8 hybrid exhibited slow-release behaviors and sustained B delivery was achieved long-term biological control over a period of at–30 days.