Statin在治療卵巢癌的檢視

The role of statin use in ovarian cancer patients

Statin除能夠與HMGCoA（3-hydroxy-methyl-glutaryl coenzyme A）來競爭的一種抑制劑，並阻止mevalonate的途徑來減少血液中膽固醇的生成，另有抗氧化、誘導自然凋亡、抗發炎、抗血管增生和抗增殖等功效，故被用在癌症患者。許多報告認為，持續使用statin能減少卵巢癌的發生率、改善生存率，但亦有其它研究認為無效，故有待日後更多相關研究加以證實。

Statins, which are competitive inhibitor of HMGCoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase, reduce cholesterol blood levels. Because they can down regulate products of the mevalonate pathway. In addition to this main activity, statins show pleiotropic effects such as antitoxidant, induce apoptosis, anti-inflammatory, anti-angiogenenic, and anti-proliferative pro-perties. These seem to support the beneficial effect and the mechanism of statin use on cancer patients. Several studies demonstrated the persistent use of statins were associated with a lower ovarian cancer risk, and improved survival rate, but other studies reported no effect. Therefore, more studies are needed to clarify these controversial results.