Based on the experience of blood collection and supply during the 2003 SARS outbreak, the Taiwan Blood Services Foundation (TBSF) established guidelines to safeguard donation sites, blood donors, staffs and blood components during the COVID-19 pandemic. Maintaining sufficient blood supplies is essential. Comparing data from March to August 2020 with the same period in the previous year, the number of donated units showed the greatest decline (-10.2%) in March but rose 6.6% in May. In terms of blood supply, the largest drop (-6.8%) was in April, followed by an increase (7.5%) in June. With the efforts of blood donors, social groups, blood center workers, and government agencies and under the policies established by the TBSF, blood centers were able to provide safe and adequate quantities of blood components to patients during the COVID-19 pandemic.