A nurse practitioner (NP) is an advanced nurse in Taiwan who has a national license and work with physicians to provide patient care. A NP needs to cross the differences in roles and perspectives between healthcare providers in the role conversion process. Clinical reasoning is the most critical professional care ability of a NP. However, the logic inferential thinking ability is not innate. In addition to reconstructing thinking mode through education and training, a NP needs to accumulate clinical experience continuously in order to establish parallel partnerships with inter-professional members. This article introduces the problems faced by the NP in the process of role transition, the importance of clinical reasoning training, and illustrates the application of reasoning teaching strategies according to three learning stages. Finally, the article discusses how to apply the skill of debriefing to promote learners’ self-reflection. Hopefully, the NP is able to internalize the clinical professional strength through reasoning training to improve the quality of patient care and establish the professional status.